Table 2.
Gross observations from neonatally treated BALB/c mice at 20 months of age.
| Neonatal treatment (μg/pup/day) | DVO (mean ± SE) | Body weight (g; mean ± SE) | Mortalitya (%) | No.b |
|---|---|---|---|---|
| Oil | 23.8 ± 0.6 | 25.0 ± 0.37 | 9 | 35 |
| E2 (5) | 10.5 ± 0.4* | 23.0 ± 0.43* | 16 | 43 |
| E2 (2.5) plus OH-PCB-30 (100) | 10.9 ± 0.4* | 24.8 ± 0.50 | 21 | 24 |
| OH-PCB-30 (200) | 11.1 ± 0.2* | 24.6 ± 0.40 | 31** | 32 |
| OH-PCB-30 (20) | 24.8 ± 0.4 | 24.8 ± 0.51 | 21 | 39 |
| OH-PCB-61 (400) | 12.4 ± 0.4* | 24.7 ± 0.40 | 33** | 33 |
| OH-PCB-61 (40) | 17.7 ± 0.8* | 25.0 ± 0.44 | 19 | 31 |
| OH-PCB-30/61 (100 + 100)c | 12.1 ± 0.4* | 25.7 ± 0.62 | 30** | 27 |
| OH-PCB-30/61 (10 + 10)c | 22.4 ± 0.6 | 25.3 ± 0.33 | 18 | 40 |
DVO, day of vaginal opening. Pups were treated as described in “Materials and Methods.”
a
Percentage of animals that died before the end of the study.
b
Number of animals used for study.
c
Equal concentrations of OH-PCB-30 and OH-PCB-61 were used as a mixture.
*p < 0.05 versus sesame oil control (Tukey-HSD test).
**p < 0.05 versus sesame oil control (Wilcoxon rank sum test).