Table 4.
Interactive effects on frequency of carcinoma types in the CV tract.
| Percent frequency
|
|||
|---|---|---|---|
| Neonatal treatment (μg/pup/day) | Total incidencea | Squamous | Adenosquamous |
| E2 (5) | 16/37b | 41 (15/37) | 8 (3/37) |
| OH-PCB-30 (200) | 10/22b | 36 (8/22) | 14 (3/22) |
| OH-PCB-61 (400) | 5/24 | 13 (3/24) | 8 (2/24) |
| E2 (2.5)/OH-PCB-30 (100) | 9/19 | 16 (3/19) | 32 (6/19)* |
| OH-PCB-30/61 (100 + 100)c | 8/21 | 14 (3/21) | 24 (5/21) |
Pups were treated as described in “Materials and Methods.”
a
Total incidence is the number of CV tract tumors per total number of mice treated.
b
Some mice had more than one type of CV tract tumor.
c
Equal concentrations of OH-PCB-30 and OH-PCB-61 were used as a mixture.
*p < 0.05 versus a combination of E2 (5) and OH-PCB-30 (200), Fisher exact test.