Table 2.
Ratio of juvenile to adult cancer potency
|
|||||||||
---|---|---|---|---|---|---|---|---|---|
Compound | Species, strain | Sex | Dose | Tumor | Geometric mean | 2.5% | Median | 97.5% | Reference |
Benzidine | Mice (B6C3F1) | Male | Liver | 111 | 64 | 110 | 198 | Vesselinovitch et al. 1975b | |
Female | Liver | 0.16 | 0.004 | 0.22 | 1.1 | ||||
3-Methylcholanthrenea | Mice (albino) | Male | 0.25 mg/g | Hepatoma | 33 | 7.4 | 30 | 268 | Klein 1959 |
Female | 0.25 mg/g | Hepatoma | 7.7 | 1.1 | 7.1 | 85 | |||
Male | 0.25 mg/g | Forestomach | 0.91 | 0.39 | 0.91 | 2.1 | |||
Female | 0.25 mg/g | Forestomach | 1.5 | 0.58 | 1.5 | 4.2 | |||
Male | 0.25 mg/g | Skin | 1.8 | 0.048 | 2.1 | 22 | |||
Female | 0.25 mg/g | Skin | 1.5 | 0.023 | 1.8 | 21 | |||
Safrole | Mice (B6C3F1) | Male | Liver | 46 | 16 | 44 | 198 | Vesselinovitch et al. 1979b | |
Female | Liver | 0.12 | 0.002 | 0.18 | 1.1 | ||||
Vinyl chlorideb | Rats (Sprague-Dawley) | Male | 10,000 ppm | Liver angiosarcoma | 7.4 | 0.035 | 11 | 62 | Maltoni et al. 1984 |
Female | 10,000 ppm | Liver angiosarcoma | 30 | 8.7 | 29 | 121 | |||
Male | 10,000 ppm | Zymbal gland | 0.27 | 0.0022 | 0.4 | 5.4 | |||
Female | 10,000 ppm | Zymbal gland | 0.15 | 0.0014 | 0.19 | 4.5 | |||
Male | 10,000 ppm | Leukemia | 21 | 0.026 | 37 | 514 | |||
Female | 10,000 ppm | Leukemia | 0.29 | 0.0019 | 0.35 | 17 | |||
Male | 10,000 ppm | Nephroblastomas | 0.17 | 0.0015 | 0.21 | 6.2 | |||
Female | 10,000 ppm | Nephroblastomas | 0.24 | 0.0017 | 0.29 | 11 | |||
Male | 10,000 ppm | Angiosarcomas other sites | 0.25 | 0.0017 | 0.30 | 12 | |||
Female | 10,000 ppm | Angiosarcomas other sites | 0.32 | 0.0019 | 0.38 | 20 | |||
Male | 10,000 ppm | Angiomas and fibromas other sites | 1.4 | 0.0045 | 2.36 | 47 | |||
Female | 10,000 ppm | Angiomas and fibromas other sites | 0.52 | 0.0024 | 0.63 | 41 | |||
Male | 10,000 ppm | Hepatoma | 34 | 8.2 | 32 | 218 | |||
Female | 10,000 ppm | Hepatoma | 55 | 8.4 | 53 | 513 | |||
Male | 10,000 ppm | Skin carcinomas | 0.41 | 0.0024 | 0.56 | 15 | |||
Female | 10,000 ppm | Skin carcinomas | 0.31 | 0.0019 | 0.37 | 19 | |||
Male | 10,000 ppm | Neuroblastoma | 0.20 | 0.0016 | 0.24 | 8.5 | |||
Female | 10,000 ppm | Neuroblastoma | 0.14 | 0.0014 | 0.18 | 4.4 |
Formerly known as 20-methylcholanthrene.
Results for 6,000 ppm are similar to those for 10,000 ppm and are given in Supplementary Table S4 (http://ehp.niehs.nih.gov/docs/2005/7667/supp.pdf).