Table 2.

Ratio of early-life to adult cancer potencies for studies with repeat exposures of juvenile and adult animals to mutagenic chemicals.

					Ratio of juvenile to adult cancer potency
Compound	Species, strain	Sex	Dose	Tumor	Geometric mean	2.5%	Median	97.5%	Reference
Benzidine	Mice (B6C3F1)	Male		Liver	111	64	110	198	Vesselinovitch et al. 1975b
		Female		Liver	0.16	0.004	0.22	1.1
3-Methylcholanthrenea	Mice (albino)	Male	0.25 mg/g	Hepatoma	33	7.4	30	268	Klein 1959
		Female	0.25 mg/g	Hepatoma	7.7	1.1	7.1	85
		Male	0.25 mg/g	Forestomach	0.91	0.39	0.91	2.1
		Female	0.25 mg/g	Forestomach	1.5	0.58	1.5	4.2
		Male	0.25 mg/g	Skin	1.8	0.048	2.1	22
		Female	0.25 mg/g	Skin	1.5	0.023	1.8	21
Safrole	Mice (B6C3F1)	Male		Liver	46	16	44	198	Vesselinovitch et al. 1979b
		Female		Liver	0.12	0.002	0.18	1.1
Vinyl chlorideb	Rats (Sprague-Dawley)	Male	10,000 ppm	Liver angiosarcoma	7.4	0.035	11	62	Maltoni et al. 1984
		Female	10,000 ppm	Liver angiosarcoma	30	8.7	29	121
		Male	10,000 ppm	Zymbal gland	0.27	0.0022	0.4	5.4
		Female	10,000 ppm	Zymbal gland	0.15	0.0014	0.19	4.5
		Male	10,000 ppm	Leukemia	21	0.026	37	514
		Female	10,000 ppm	Leukemia	0.29	0.0019	0.35	17
		Male	10,000 ppm	Nephroblastomas	0.17	0.0015	0.21	6.2
		Female	10,000 ppm	Nephroblastomas	0.24	0.0017	0.29	11
		Male	10,000 ppm	Angiosarcomas other sites	0.25	0.0017	0.30	12
		Female	10,000 ppm	Angiosarcomas other sites	0.32	0.0019	0.38	20
		Male	10,000 ppm	Angiomas and fibromas other sites	1.4	0.0045	2.36	47
		Female	10,000 ppm	Angiomas and fibromas other sites	0.52	0.0024	0.63	41
		Male	10,000 ppm	Hepatoma	34	8.2	32	218
		Female	10,000 ppm	Hepatoma	55	8.4	53	513
		Male	10,000 ppm	Skin carcinomas	0.41	0.0024	0.56	15
		Female	10,000 ppm	Skin carcinomas	0.31	0.0019	0.37	19
		Male	10,000 ppm	Neuroblastoma	0.20	0.0016	0.24	8.5
		Female	10,000 ppm	Neuroblastoma	0.14	0.0014	0.18	4.4

^aFormerly known as 20-methylcholanthrene.

^bResults for 6,000 ppm are similar to those for 10,000 ppm and are given in Supplementary Table S4 (http://ehp.niehs.nih.gov/docs/2005/7667/supp.pdf).