Table 5.
Ratio of juvenile to adult cancer potency
|
|||||||||
---|---|---|---|---|---|---|---|---|---|
Compound | Species, strain | Sex | Dose | Tumor | Geometric mean | 2.5% | Median | 97.5% | References |
Amitrole | Mice (B6C3F1) | Male | 500 | Liver | 13 | 5.1 | 14 | 30 | Vesselinovitch 1983 |
Female | 500 | Liver | 0.14 | 0.0013 | 0.18 | 3.9 | |||
DDT | Mice (B6C3F1) | Male | 150 | Liver | 1.3 | 0.0044 | 2.5 | 25 | Vesselinovitch et al. 1979a |
Dieldrin | Mice (B6C3F1) | Male | 10 | Liver | 0.75 | 0.0031 | 1.2 | 27 | Vesselinovitch et al. 1979a |
DPH | Rats (F344/N) | Male | 630 | Liver | 0.40 | 0.0024 | 0.54 | 16 | Chhabra et al. 1993b |
Female | 630 | Liver | 0.24 | 0.0017 | 0.29 | 12 | |||
Mice (B6C3F1) | Male | 210 | Liver | 1.5 | 0.0040 | 2.4 | 71 | ||
Female | 210 | Liver | 1.3 | 0.0056 | 2.6 | 15 | |||
ETU | Rats (F344/N) | Male | 90 | Thyroid | 0.37 | 0.0029 | 0.61 | 5.4 | Chhabra et al. 1992 |
Female | 90 | Thyroid | 0.23 | 0.0018 | 0.30 | 7.0 | |||
Mice (B6C3F1) | Male | 330 | Liver | 0.091 | 0.0011 | 0.12 | 1.9 | ||
Female | 330 | Liver | 0.057 | 0.0010 | 0.081 | 0.65 | |||
Male | 330 | Thyroid | 0.41 | 0.0022 | 0.52 | 25 | |||
Female | 330 | Thyroid | 0.40 | 0.0024 | 0.55 | 16 | |||
Male | 330 | Pituitary | 0.32 | 0.0019 | 0.38 | 22 | |||
Female | 330 | Pituitary | 0.24 | 0.0018 | 0.32 | 6.9 | |||
PBB | Rats (F344/N) | Male | 10 | Liver | 0.59 | 0.0041 | 1.1 | 6.6 | Chhabra et al. 1993a |
Female | 10 | Liver | 0.063 | 0.0009 | 0.079 | 1.2 | |||
Male | 10 | Mononuclear cell leukemia | 0.79 | 0.0035 | 1.4 | 18 | |||
Female | 10 | Mononuclear cell leukemia | 0.21 | 0.0017 | 0.28 | 6.0 | |||
Mice (B6C3F1) | Male | 30 | Liver | 3.9 | 1.9 | 3.9 | 7.5 | ||
Female | 30 | Liver | 1.0 | 0.37 | 1.05 | 2.1 |