Table 5.

Ratio of early-life to adult cancer potencies for studies with repeated exposures of juvenile and adult animals to nonmutagenic chemicals.

					Ratio of juvenile to adult cancer potency
Compound	Species, strain	Sex	Dose	Tumor	Geometric mean	2.5%	Median	97.5%	References
Amitrole	Mice (B6C3F1)	Male	500	Liver	13	5.1	14	30	Vesselinovitch 1983
		Female	500	Liver	0.14	0.0013	0.18	3.9
DDT	Mice (B6C3F1)	Male	150	Liver	1.3	0.0044	2.5	25	Vesselinovitch et al. 1979a
Dieldrin	Mice (B6C3F1)	Male	10	Liver	0.75	0.0031	1.2	27	Vesselinovitch et al. 1979a
DPH	Rats (F344/N)	Male	630	Liver	0.40	0.0024	0.54	16	Chhabra et al. 1993b
		Female	630	Liver	0.24	0.0017	0.29	12
	Mice (B6C3F1)	Male	210	Liver	1.5	0.0040	2.4	71
		Female	210	Liver	1.3	0.0056	2.6	15
ETU	Rats (F344/N)	Male	90	Thyroid	0.37	0.0029	0.61	5.4	Chhabra et al. 1992
		Female	90	Thyroid	0.23	0.0018	0.30	7.0
	Mice (B6C3F1)	Male	330	Liver	0.091	0.0011	0.12	1.9
		Female	330	Liver	0.057	0.0010	0.081	0.65
		Male	330	Thyroid	0.41	0.0022	0.52	25
		Female	330	Thyroid	0.40	0.0024	0.55	16
		Male	330	Pituitary	0.32	0.0019	0.38	22
		Female	330	Pituitary	0.24	0.0018	0.32	6.9
PBB	Rats (F344/N)	Male	10	Liver	0.59	0.0041	1.1	6.6	Chhabra et al. 1993a
		Female	10	Liver	0.063	0.0009	0.079	1.2
		Male	10	Mononuclear cell leukemia	0.79	0.0035	1.4	18
		Female	10	Mononuclear cell leukemia	0.21	0.0017	0.28	6.0
	Mice (B6C3F1)	Male	30	Liver	3.9	1.9	3.9	7.5
		Female	30	Liver	1.0	0.37	1.05	2.1