Table 3.
Summary of the database by predominant modes of elimination.
| Route of elimination | No. of drugs | Individual data points | Data groupsa | Subjects in data groups (n) | Total no. of subjects |
|---|---|---|---|---|---|
| All CYPs | 19 | 389 | 126 | 2,315 | 2,704 |
| Conjugation | 5 | 122 | 6 | 60 | 182 |
| Other metabolism | 4 | 18 | 18 | 114 | 132 |
| Renal and/or fecal elimination | 14 | 278 | 51 | 892 | 1,170 |
| Unclassified | 4 | 78 | 14 | 247 | 325 |
| Total | 46 | 885 | 215 | 3,628 | 4,513 |
a
Data sets where pooled (e.g., mean, SD) rather than individual data are available for the indicated parameter.