Skip to main content

View full-text article in PMC

. 2002 Jul;70(7):3324–3329. doi: 10.1128/IAI.70.7.3324-3329.2002

TABLE 1.

Duration of anti-B. melitensis LPS IgG in mouse sera after intranasal immunization with B. melitensis LPS-GBOMP vaccine^a

Vaccine dose	Time (wk) after vaccine dose	OD units (mean ± SD)^b
Vaccine dose	Time (wk) after vaccine dose	IgG	IgG1	IgG2a	IgG2b	IgG3
First	2	348 ± 273	183 ± 197	30 ± 20	33 ± 37	92 ± 73
	4	1,365 ± 464	988 ± 290	57 ± 43	73 ± 16	367 ± 143
Second	2	27,332 ± 14,980	22,341 ± 10,983	217 ± 113	385 ± 322	2,111 ± 829
	4	25,373 ± 9,477	23,805 ± 9,529	461 ± 217	288 ± 92	1,413 ± 393
	8	27,267 ± 13,358	19,620 ± 8,363	470 ± 412	274 ± 145	1,257 ± 494
	12	26,675 ± 11,290	21,136 ± 6,902	194 ± 134	215 ± 78	1,075 ± 483
	16	23,830 ± 13,527	21,756 ± 14,270	245 ± 179	318 ± 90	1,031 ± 450
	19	7,314 ± 4,801	6,387 ± 3,094	298 ± 163	20 ± 5	507 ± 163
	21	10,564 ± 6,439	11,896 ± 8,166	193 ± 84	20 ± 7	591 ± 266
	25	8,633 ± 3,723	7,740 ± 2,942	176 ± 188	15 ± 6	412 ± 267

^a

Mice were immunized twice intranasally 4 weeks apart with B. melitensis LPS-GBOMP vaccine. Sera were collected at the times indicated for ELISA.

^b

Data are for 10 animals at each time point. Negative control sera run simultaneously in these assays had titers of less than 1 OD unit.