TABLE 3.

Anti-B. melitensis LPS serum IgG after intranasal challenge^a

Vaccine	Time point	Anti-LPS IgG (mean ± SD)b
B. melitensis LPS- GBOMP	4 wk after first dose	4,421 ± 2,368
	4 wk after second dose	26,705 ± 17,258
	3 days after challenge	11,970 ± 10,644
	9 days after challenge	13,495 ± 5,563
	8 wk after challenge	10,547 ± 4,810
Saline control	4 wk after first and second doses	<10
	3 and 9 days after second challenge	<10
	8 wk after challenge	19,765 ± 11,416

^aMice were immunized intranasally with two doses of vaccine or saline 4 weeks apart and then challenged 4 weeks after the second dose. Sera were collected for ELISA at the times indicated.

^bData are expressed as OD units. n = 5 mice for all time points except 8 weeks; at 8 weeks, n = 15 mice.