TABLE 4.
Anti-B. melitensis LPS IgG and IgA in BAL fluid from immunized and control micea
| Vaccine dose | Vaccine | Titer (mean ± SD)b
|
|
|---|---|---|---|
| IgG | IgA | ||
| First | B. melitensis LPS-GBOMP | 56 ± 52 | 3 ± 2 |
| Saline control | <1 | <1 | |
| Second | B. melitensis LPS-GBOMP | 202 ± 132 | 10 ± 15 |
| Saline control | <1 | <1 | |
a
Mice were immunized intranasally with two doses of vaccine or saline 4 weeks apart. BAL fluid was collected for ELISA 4 weeks after the indicated vaccine dose.
b
Mean ELISA OD units obtained from five mice per group.