Table 2.
Association of AXIN1 polymorphisms with PD risk in sex-based subgroups in Northern Han Chinese
| SNPs | Male | OR (95% CI) | P | Pc | Female | OR (95% CI) | P | Pc | ||
|---|---|---|---|---|---|---|---|---|---|---|
| rs13337493 (G > A) | PD (N = 249) | HC (N = 255) | PD (N = 230) | HC (N = 206) | ||||||
| Allele frequency, n (%) | ||||||||||
| Major allele G | 386 (77.5) | 418 (82.0) | Reference | 358 (77.8) | 339 (82.3) | Reference | ||||
| Minor allele A | 112 (22.5) | 92 (18.0) | 1.318 (0.968, 1.818) | 0.085 | 0.170 | 102 (22.2) | 73 (17.7) | 1.323 (0.946, 1.848) | 0.060 | 0.120 |
| Genotype frequency, n (%) | ||||||||||
| Dominant | ||||||||||
| GG | 151 (60.7) | 173 (67.8) | Reference | 137 (59.6) | 136 (66.0) | Reference | ||||
| GA + AA | 98 (39.3) | 82 (32.2) | 1.369 (0.950, 1.974) | 0.920 | 1.000 | 93 (40.4) | 70 (34.0) | 1.319 (0.893, 1.949) | 0.164 | 0.328 |
| Recessive | ||||||||||
| GG + GA | 235 (94.4) | 245 (96.1) | Reference | 221 (96.1) | 203 (98.5) | Reference | ||||
| AA | 14 (5.6) | 10 (3.9) | 1.345 (0.586, 3.085) | 0.483 | 0.966 | 9 (3.9) | 3 (1.5) | 2.756 (0.736, 10.320) | 0.203 | 0.406 |
| Additive | ||||||||||
| GG | 151 (60.7) | 173 (67.8) | Reference | 137 (59.6) | 136 (66.0) | Reference | ||||
| GA | 84 (33.7) | 72 (28.2) | 1.337 (0.911, 1.961) | 0.137 | 0.274 | 84 (36.5) | 67 (32.5) | 1.245 (0.835, 1.855) | 0.282 | 0.564 |
| AA | 14 (5.6) | 10 (4.0.) | 1.604 (0.692, 3.717) | 0.267 | 0.534 | 9 (3.9) | 3 (1.5) | 2.978 (0.789, 11.238) | 0.165 | 0.330 |
| HWE | P = 0.771 | P = 0.253 | ||||||||
| rs9921222 (C > T) | PD (N = 249) | HC (N = 219) | PD (N = 230) | HC (N = 163) | ||||||
| Allele frequency, n (%) | ||||||||||
| Major allele C | 402 (80.7) | 378 (86.3) |
Reference 1.635 (1.161–2.303) |
374 (81.3) | 273 (83.7) | Reference | ||||
| Minor allele T | 96 (19.3) | 60 (13.7) | 1.504 (1.058, 2.139) | 0.022 | 0.044* | 86 (18.7) | 53 (16.3) | 1.184 (0.813, 1.725) | 0.377 | 0.754 |
| Genotype frequency, n (%) | ||||||||||
| Dominant | ||||||||||
| CC | 162 (65.1) | 161 (73.5) | Reference | 149 (64.8) | 114 (69.9) | Reference | 0.284 | 0.568 | ||
| CT + TT | 87 (34.9) | 58 (26.5) | 1.491 (1.002, 2.218) | 0.048 | 0.096 | 81 (35.2) | 49 (30.1) | 1.265 (0.822, 1.945) | ||
| Recessive | ||||||||||
| CC + CT | 240 (96.4) | 217 (99.1) | Reference | 225 (97.8) | 159 (97.5) | Reference | 1.000 | 1.000 | ||
| TT | 9 (3.6) | 2 (0.9) | 4.744 (1.015, 22.179) | 0.062 | 0.124 | 5 (2.2) | 4 (2.5) | 0.883 (0.234, 3.341) | ||
| Additive | ||||||||||
| CC | 162 (65.1) | 161 (73.5) | Reference | 149 (64.8) | 114 (69.9) | Reference | ||||
| CT | 78 (31.3) | 56 (25.6) | 1.384 (0.922, 2.079) | 0.117 | 0.234 | 76 (33.0) | 45 (27.6) | 1.292 (0.831, 2.010) | 0.305 | 0.610 |
| TT | 9 (3.6) | 2 (0.9) | 4.472 (0.951, 21.021) | 0.079 | 0.158 | 5 (2.2) | 4 (2.5) | 0.956 (0.251, 3.642) | 1.000 | 1.000 |
| HWE | P = 0.486 | P = 0.984 | ||||||||
Categorical variables were compared using Pearson’s χ2 test; * Pc < 0.05, statistical significance
PD Parkinson’s disease, HC healthy control, OR odds ratio, 95% CI 95% confidence interval, HWE Hardy–Weinberg equilibrium, PC Bonferroni correction