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Hemozoin upregulates DC surface markers. Elutriated human monocytes were incubated with GM-CSF and IL-4, and immature DCs were further incubated with 10 μM HZ, β-hematin, or heme for 36 h. Upregulation of CD83, CD86, and CD1a surface markers was measured by FACS analysis. The data shown are representative of two experiments repeated with two independent preparations of highly purified HZ.
