Figure 1.

Overview of the scMOVIR workflow. (A) Systematic collection of single-cell multi-omics datasets related to viral infections from literature and multiple public repositories. All datasets undergo stringent QC and preprocessing, supplemented by manual curation and comprehensive metadata harmonization to ensure consistency and accuracy. (B) Downstream analyses and visualization are performed for each omics modality. Transcriptomic analyses encompass cell UMAP projection, cell-type composition, differential gene expression, functional enrichment, and cell–cell communication. Proteomic analyses involve the identification of differentially expressed proteins. Immune repertoire analyses include quantification of clonal abundance, repertoire diversity, and VJ gene usage patterns.