TABLE 3.
Protection of OspE-related, OspF-related, and Elp protein-vaccinated mice from challenge with infected ticks
| Immunogen | No. of cultures positive/no. testeda |
|---|---|
| OspA | 0/5 |
| GST | 5/5 |
| OspE | 5/5 |
| p21 | 5/5 |
| OspF | 5/5 |
| BbK2.11 | 5/5 |
| BbK2.10 | 5/5 |
| ElpA1 | 5/5 |
| ElpA2 | 5/5 |
| ElpB1 | 5/5 |
| ElpB2 | 5/5 |
| OspE related | 5/5 |
| OspF related | 5/5 |
| Elps | 5/5 |
| OspE related, OspF related, and Elps | 5/5 |
a
Two weeks after infestation, ear punch biopsies were cultivated in BSK-H medium containing rifampin and amphotericin B. Cultures were examined over a 3-week period and considered positive if spirochetes were observed at any point by dark-field microscopy. For OspA, heart, spleen, and bladder biopsies also were cultured.