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. 2025 Dec 9;17:594. doi: 10.1038/s41467-025-67297-0

Fig. 5. Crystal structures of MITF in complex with fragments 3 and 4.

Fig. 5

a, b MITF(217-296) in complex with 3 (PDB ID: 9H7Q, ligand in yellow) or 4 (PDB ID: 9H5H, ligand in orange). The kinked helix A is shown in green, the straight helix B in cyan, and the third helix in purple. The pocket is viewed from the same side in both panels. c, d Ligand interactions diagram for MITF(217-296) in complex with fragments 3 and 4. In (a and b), the chain A, B and C labeled in the diagrams are reported in green, cyan and purple. The hydrogen bonds are shown as purple arrows.