Skip to main content
. 2025 Dec 19;25:100332. doi: 10.1016/j.cpnec.2025.100332

Table 3.

Mediating effects of physical activity and diet.

Mediator Physical activity Diet
Obesity phenotype: BMI ≥ 30 only vs healthy non-obese
Total effect 1.12 (1.00,1.26) 1.15 (1.04,1.27)
Natural direct effect 1.12 (1.00,1.26) 1.15 (1.04,1.27)
Natural indirect effect 1.00 (1.00,1.01) 1.00 (1.00,1.00)
Proportion mediated 2.49 % (0.24 %,17.49 %) 1.60 % (0.34 %,5.55 %)
Obesity phenotype: metabolically unhealthy obesity vs healthy non-obese
Total effect 1.52 (1.46,1.60) 1.57 (1.49,1.64)
Natural direct effect 1.49 (1.42,1.56) 1.56 (1.48,1.63)
Natural indirect effect 1.02 (1.02,1.03) 1.01 (1.00,1.01)
Proportion mediated 7.08 % (4.87 %,9.43 %) 1.86 % (0.91 %,2.74 %)
Obesity phenotype: central obesity vs healthy non-obese
Total effect 1.60 (1.49,1.71) 1.61 (1.51,1.70)
Natural direct effect 1.57 (1.46,1.68) 1.60 (1.50,1.69)
Natural indirect effect 1.02 (1.01,1.03) 1.01 (1.00,1.01)
Proportion mediated 5.29 % (3.52 %,7.34 %) 1.47 % (0.58 %,2.50 %)
Obesity phenotype: sarcopenic obesity vs healthy non-obese
Total effect 1.53 (1.09,2.12) 1.74 (1.32,2.30)
Natural direct effect 1.50 (1.07,2.08) 1.73 (1.31,2.28)
Natural indirect effect 1.02 (1.01,1.04) 1.01 (1.00,1.01)
Proportion mediated 6.22 % (2.67 %,17.05 %) 1.25 % (0.41 %,3.10 %)

Note.

Covariates: sex, age, race, education qualifications, smoking status, drinking status, family history of depression, diabetes, and hypertension.