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Normalization of pancreatic islet morphology in males. (A and B) Nse+Syn db/db and +/+ mice have comparable islet morphology. (C and D) The SYN-LEPR-B transgene shows a dosage-dependent rescue of islet morphology. (E) Obese control demonstrating enlarged pancreatic islet. Genotypes are indicated. Magnification, ×20.
