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. 2005 Nov 10;115(12):3460–3472. doi: 10.1172/JCI24858

Figure 9.

Figure 9

Role of CCR5 in IFN-γ regulation of cell death pathways. (A, D, and F) Tg– and Tg+ mice were placed on dox water and treated with anti-CCR5 or control Ig. (B, C, E, and G) CCR5+/+ and CCR5–/– Tg– and Tg+ mice were treated with dox water for 4 weeks. mRNA was evaluated by RT-PCR (A and B) and real-time RT-PCR (C). BAL TNF levels were evaluated by ELISA (D and E). (F) Caspase-3, -8, and -9, Bid, and truncated Bid (tBid) were evaluated by Western blot analysis. (G) Caspase bioactivity was evaluated. Each evaluation in A, B, and F is representative of a minimum of 4 similar experiments. The values in the remaining panels represent the mean ± SEM of evaluations in a minimum of 5 animals. *P < 0.05.