FIG. 1.

Percentage of bone surface covered by osteoclasts in mice challenged with a low dose of LPS. All mice received a one-time low dose of LPS (100 μg/mouse) (LPS100) or saline, which was followed by anti-IL-11 MAb (four injections of 465 μg/mouse), indomethacin (Indo) (nine injections of 50 μg/mouse), or PBS injections. Mice were sacrificed on day 5. Bars represent means (error bars, SD), and n was 7 for each group. Symbols: ∗∗ and ∗∗∗, P < 0.01 and P < 0.001, respectively (for comparison with wild-type mice in the LPS100+PBS group); #, P < 0.01 (for comparison with mice of the same strain in the other three groups).