FIG. 3.

Light micrographs of mouse calvaria injected with 500 μg of LPS and treated with either PBS (panels 1), anti-IL-11 MAb (panels 2), or indomethacin (panels 3) in wild-type (A), IL-1RI^−/− (B), and TNFRp55^−/−-IL-1RI^−/− (C) mice. Histological sections of the calvarial bone were stained for TRAP and counterstained with hematoxylin. An arrow indicates TRAP-positive (red-staining) multinucleated cells in Howship's lacunae. Abbreviations: BM, bone marrow; Indo, indomethacin. Magnification, ×200.