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. 2002 Jul;70(7):3673–3680. doi: 10.1128/IAI.70.7.3673-3680.2002

FIG. 6.

FIG. 6.

Transepithelial fluxes of FITC-dextran 3000 across nontransformed human duodenal epithelial SCBN monolayers incubated with either 5% DMEM, G. lamblia NF sonicates, or G. lamblia sonicates after pretreatment with the caspase-3 inhibitor Z-DEVD-FMK 24 (A) and 48 (B) h postinoculation. Exposure to G. lamblia significantly increases transepithelial permeability. Pretreatment with a caspase-3 inhibitor abolishes the Giardia-induced effect. Values are means ± standard errors of the means (n = 4 per group). ∗, P < 0.05; ∗∗, P < 0.01 versus control.