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Flow diagrams depicting (A) selection of cases included in the study. LGSC – low-grade serous carcinoma; HGSC – high-grade serous carcinoma; LGS-HT – low-grade serous tumors with histologic transformation (Sync – synchronous, Metac – metachronous); NGS – next-generation sequencing; (B) diagnostic algorithm for assigning histologic grade in ovarian serous neoplasms, as applied to homogenous tumors and individual tumor components within LGS-HTs.
