. 2002 Jul;70(7):3681–3688. doi: 10.1128/IAI.70.7.3681-3688.2002

TABLE 5.

Increased protective efficacy of Ag85B DNA against intravenous M. tuberculosis challenge by formulation in Vaxfectin

Organ	Vaccine	Mean log₁₀ mRLU/organ ± SD following M. tuberculosis challenge at wk indicated (no. of animals) [change]
Organ	Vaccine	2	4	8
Lungs	None	4.76 ± 0.20 (5)^a [+0.41]	4.94 ± 0.34 (7)^a [−0.32]	5.29 ± 0.22 (7)^a [+0.04]
	Control DNA	4.35 ± 0.25 (5)	5.26 ± 0.14 (5)	5.25 ± 0.20 (3)
	M. bovis BCG	3.43 ± 0.28 (3)^b [−0.92]	3.51 ± 0.02 (2)^b [−1.75]	4.36 ± 0.46 (2)^b [−0.91]
	Ag85B-saline	3.92 ± 0.31 (5)^a^,^c [−0.43]	4.79 ± 0.18 (5)^d^,^f [−0.47]	5.10 ± 0.16 (5)^a^,^f [−0.15]
	Ag85B-Vaxfectin	3.49 ± 0.18 (5)^b [−0.86]	4.28 ± 0.22 (5)^b [−0.98]	4.45 ± 0.26 (5)^b [−0.80]
Spleen	None	4.45 ± 0.09 (5)^a [+0.23]	3.86 ± 0.12 (7)^a [−0.27]	3.96 ± 0.22 (7)^a [+0.15]
	Control DNA	4.22 ± 0.13 (5)	4.13 ± 0.19 (5)	3.81 ± 0.20 (3)
	M. bovis BCG	3.47 ± 0.06 (3)^b [−0.75]	3.47 ± 0.02 (2)^b [−0.66]	3.87 ± 0.58 (2)^a [+0.06]
	Ag85B-saline	4.16 ± 0.05 (5)^a^,^e [−0.06]	4.02 ± 0.28 (6)^a^,^e [−0.11]	3.74 ± 0.04 (5)^a^,^e [−0.07]
	Ag85B-Vaxfectin	4.16 ± 0.16 (5)^a [−0.06]	3.77 ± 0.14 (5)^d [−0.36]	3.64 ± 0.14 (5)^a [−0.17]

Not significant compared to results obtained with control DNA.

For a comparison with control DNA, the P value was <0.005.

For a comparison with Ag85B DNA in Vaxfectin, the P value was <0.025.

For a comparison with control DNA, the P value was <0.05.

Not significant compared to results obtained with Ag85B DNA in Vaxfectin.

For a comparison with Ag85B DNA in Vaxfectin, the P value was <0.005.