Table 5. Immunisation effectiveness against RSV hospitalisation in children (< 2 years) residing in jurisdictions with population-based nirsevimab programmes, Queensland and Western Australia, Australia, 2024 (n = 800).
| Immunisation effectiveness by age | Number of RSV-positive cases | Number of RSV-negative controls | OR | 95% CI | aOR | 95% CI | Nirsevimab effectiveness | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Imm | Unimm | Imm | Unimm | |||||||
| RSV hospitalisation | ||||||||||
| < 6 months | 26 | 108 | 34 | 56 | 0.397 | 0.217 to 0.725 | 0.191a | 0.071 to 0.513 | 80.9%a | 48.7 to 92.9 |
| < 12 months | 37 | 222 | 58 | 99 | 0.284 | 0.177 to 0.458 | 0.169a | 0.087 to 0.326 | 83.1%a | 67.4 to 91.3 |
| 12–23 months | 12 | 305 | 7 | 60 | 0.362 | 0.139 to 0.944 | 0.766a | 0.222 to 2.645 | 23.4%a | −100 to 77.8 |
| RSV-associated ICU/HDU admission | ||||||||||
| < 12 months | 4 | 15 | 9 | 6 | 0.177 | 0.039 to 0.806 | 0.085b | 0.004 to 1.611 | 91.5%b | −61.1 to 99.5 |
aOR: adjusted odds ratio; CI: confidence interval; HDU: high dependency unit; ICU: intensive care unit; Imm: immunised; OR: odds ratio; RSV: respiratory syncytial virus; Unimm: unimmunised.
a Adjusted by age group, chronic medical conditions, First Nations status, grouped by week and state.
b Adjusted by age group, chronic medical conditions, First Nations status, grouped by month and state.
First Nations status included all Aboriginal Australian and Torres Strait Islander people based on self-report on medical records.