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. 2002 Aug;70(8):4158–4164. doi: 10.1128/IAI.70.8.4158-4164.2002

FIG. 8.

FIG. 8.

Sequence comparison with human germ line V genes. Sequence comparison of the deduced amino acid sequences of the isolated H. pylori binders (A9 and E8) and the antiurease scFv F11 revealed close homologies (between 90 and 100%) of all scFvs to their germ line V genes. The anti-H. pylori scFvs had identical heavy chains of the VH4 family which were most closely related to germ line gene DP-71 (VH4-59) and closely related kappa light chains with the highest homology to germ line gene DPK9 (O2/O12). The heavy chain of antiurease scFv F11 belonged to the VH5 family and was most closely related to germ line gene DP-73 (VH5-51). The lambda light chain (VL3 family) showed the highest homology (100%) to germ line gene DPL-16 (V2-13). % ID, identity to the germ line gene; dots denote sequence identity, and dashes denote gaps in the sequence.