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. 2025 Sep 15;19:1988. doi: 10.3332/ecancer.2025.1988

Table 2. Comparison of VAPs and VMPs OAR compliance with the dose constraints for different treatment sites.

Site Organ Dose Constraint Auto-plan: mean ± Std. Dev Manual plan: mean ± Std. Dev p-value

Head and neck
Brain stem: Dmax ≤ 54 Gy 43.6 ± 6.9 40.8 ± 13.2 0.28
Left Lens: Dmax ≤ 10 Gy 8.7 ± 7.5 5.7± 4.0 0.14
Right Lens: Dmax ≤ 10 Gy 6.7 ± 4.8 5.4 ± 3.7 0.26
Spinal cord: Dmax ≤ 45 Gy 42.2 ± 2.3 39.9 ± 5.7 0.06
Optic Chiasm: Dmax ≤ 54 Gy 24.8 ± 21.7 25.6 ± 23.4 0.47

Oesophagus
Heart: V50Gy ≤ 33% 4.3 ± 2.2 4.5 ± 1.3 0.42
Heart: Dmean ≤ 26 Gy 20.8 ± 2.6 19.0 ± 2.9 0.08
Combined Lungs: Dmean ≤ 20 Gy 13.5 ± 1.9 14.8 ± 2.3 0.11
Left Lung: V40Gy ≤ 10% 2.2 ± 1.4 2.3 ± 1.4 0.31
Right Lung: V40Gy ≤ 10% 3.1 ± 1.7 3.7 ± 2.2 0.34
Spinal cord: Dmax ≤ 45 Gy 38.6 ± 4.9 37.3 ± 7.6 0.33

Breast
Heart: Dmean ≤ 5.0 Gy 4.0 ± 1.0 8.3 ± 1.4** 0.01*
Combined Lungs: Dmean ≤ 10.0 Gy 10.3 ±1.3** 13.2 ± 0.8** 0.01*
Ipsilateral Lung: Dmean ≤ 12.0 Gy 15.4 ± 2.0** 19.5 ± 1.5** 0.01*
Contralateral Lung: Dmean ≤ 6.0 Gy 3.6 ± 1.0 4.8 ± 0.9 0.01*
Contralateral breast: Dmean ≤ 3.0 Gy 2.0 ± 0.50 3.1± 1.6** 0.02*
Spinal Cord: Dmax ≤ 39.0 Gy 6.0 ± 1.6 19.6 ± 2.3 0.01*

Prostate
Rectum: V50Gy ≤ 50% 16.5 ±4.3 30.6 ± 13.1 0.01*
Bladder: V50Gy ≤ 55% 25.4 ± 8.9 28.0 ± 11.1 0.29
Right Femoral head: Dmax ≤ 50 Gy 43.3 ± 3.5 45.7 ± 4.1 0.10
Left Femoral head: Dmax ≤ 50 Gy 45.2 ± 3.7 45.9 ± 3.9 0.34
Penile Bulb: Dmean ≤ 51 Gy 18.6 ± 12.9 24.3 ± 17.1 0.20
Bowel Bag: Dmax ≤ 52 Gy 54.0± 0.6 54.7 ± 0.6 0.31

Cervical
Rectum: V30Gy ≤ 60% 76.7 ± 18.9** 78.0 ± 18.9** 0.44
Bladder: V45Gy ≤ 35% 46.4 ± 12.8** 51.6 ± 16.5** 0.22
Bowel Bag: V40Gy ≤ 30% 14.2 ± 6.9 16.7 ± 7.2 0.22
Right Femoral head: V30Gy ≤ 15% 12.6 ± 7.6 13.8 ± 12.0 0.39
Left Femoral head: V30Gy ≤ 15% 16.0 ± 7.2 16.3 ± 11.4 0.48

Rectum
Bladder: V40Gy ≤ 40% 68.1 ± 21.2** 74.9 ± 23.1** 0.25
Bowel Bag: V40Gy ≤ 30% 14.2 ± 8.2 17.3 ± 10.0 0.22
Right Femoral head: Dmax ≤ 50 Gy 42.8 ± 8.0** 44.2 ± 5.8 0.32
Left Femoral head: Dmax ≤ 50 Gy 45.4 ± 6.0** 46.1 ± 4.0 0.39

p=statistical significance

*=p values < 0.05, ** = Dose constraint not fulfilled