FIG. 2.

Dissemination is similar in RAG^+/+ and RAG^−/− mice. B6, B6 RAG^−/−, C3H/HeN, and C3H/HeN RAG^−/− mice were sacrificed at 14 days postinfection. The numbers of M. tuberculosis CFU in the spleens (A) and lungs (B) were determined. The bars and error bars indicate the means and standard deviations, respectively, based on six mice per group. The number of lung CFU did not vary significantly among the four different strains of mice. The number of splenic CFU did not differ significantly between the B6 and B6 RAG^−/− mice or between the C3H/HeN and C3H/HeN RAG^−/− mice. Significant differences were detected between B6 and C3H/HeN mice and between B6 RAG^−/− and C3H/HeN RAG^−/− mice, as indicated. All analyses were carried out by using the one-way ANOVA with the Tukey posttest for multiple comparisons. The data are representative of the data obtained in four experiments.