TABLE 1.
Lengths numbers of introns, and chromosomal locations of P. falciparum genes involved in GPI biosynthesis and sequence similarities to homologs in human and yeast
| Gene | Chromosomea | No. of introns | Product length (amino acids) | % Amino acid identity (similarity)b
|
||
|---|---|---|---|---|---|---|
| P. falciparum vs. H. sapiens | P. falciparum vs. S. cerevisiae | S. cerevisiae vs. H. sapiens | ||||
| PIG-A | 10 | 6 | 461 | 46 (66) | 39 (64) | 45 (67) |
| GPI1 | Blob | 8 | 669 | 20 (46) | 23 (45) | 24 (47) |
| PIG-M | 12 | 7 | 441 | 37 (62) | 39 (61) | 39 (64) |
| PIG-B | 13 | 0 | 786 | 25 (50) | 24 (51) | 28 (51) |
| PIG-O | 12 | 2 | 1,238 | 24 (47) | 24 (46) | 30 (50) |
| GAA1 | 13 | 3 | 700 | 19 (40) | 20 (44) | 27 (48) |
| GPI8 | 11 | 0 | 493 | 30 (54) | 31 (56) | 47 (67) |
| DPMI | 11 | 0 | 259 | 49 (70) | 31 (48) | 32 (50) |
a
Chromosome assignments are based on database information, using the system provided by the Malaria Genome Consortium. Chromosomes 6 to 8 are not yet resolved and are referred to as the Blob.
b
Identity and similarity were computed for the optimal global pairwise alignment driven by scoring matrix BLOSUM45 with gap penalties 4 and 12. Similarity is defined by a positive score. The percentage is calculated with respect to the length of the shorter sequence. Accession numbers are provided in the figure legends.