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What determines acidosis?
| • H+ intake and endogenous H+ generation |
| • H+ excretion (TA+NH4+ - HCO3-) |
| TA (mainly phosphate) is dependent on urine pH and the amount of buffer available (i.e. phosphate balance) |
| NH4+ is dependent on NH3/NH4+ generation and delivery (PT, TAL reabsorption and CD ‘trapping’) |
| HCO3- is dependent on urine pH and pCO2 |
| TA=titratable acid; PT=proximal tubule; TAL=thick ascending limb; CD=collecting duct |
