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Effect of VPA-985 administration on urinary AQP2 excretion of heart failure patients according to dose groups. (X axis represents the collection periods. Day - 1 is the baseline observation and day + 1 is the study period. ▪ Baseline; ○ Placebo; • 30 mg; ▵ 75 mg; □ 150 mg; ♦ 250 mg) [Reprinted by permission, from Ref. 20]
