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. 2025 Dec 26;31:97. doi: 10.1186/s40001-025-03707-9

Table 3.

Mediation effects of depressive symptoms in LE8 components—NAFLD pathways (Adjusting for model 5’s covariates)

LE8 components Path coefficients and significance Total effect β (95% CI) Direct effect β₃ (95% CI) Mediating effect (β₁*β₂) Mediation proportion Mediation significance (P value)
HEI-2015 diet score β₁ = − 0.04(− 0.06, − 0.03), P < 0.001; β₂ = 0.27(0.14,0.39), P < 0.001 − 0.03(− 0.05, − 0.02), P < 0.001 − 0.03(− 0.04, − 0.01), P < 0.001 − 0.0108 5.79%  < 0.001
Physical activity score β₁ = − 0.04(− 0.06, − 0.02), P < 0.001; β₂ = 0.28(0.15,0.41), P < 0.001 − 0.01(− 0.02,0.00), P = 0.226 − 0.01(− 0.02,0.01), P = 0.342 − 0.0112 17.74%  < 0.001
Nicotine exposure score β₁ = − 0.12(− 0.15, − 0.09), P < 0.001; β₂ = 0.30(0.17,0.43), P < 0.001 0.02(0.00,0.03), P = 0.040 0.02(0.01,0.04), P = 0.010 − 0.036 − 27.55%  < 0.001
Sleep health score β₁ = − 0.14(− 0.16, − 0.11), P < 0.001; β₂ = 0.27(0.15,0.40), P < 0.001 − 0.01(− 0.03,0.01), P = 0.188 − 0.00(− 0.02,0.01), P = 0.558 − 0.0378 46.78%  < 0.001
BMI score β₁ = − 0.04(− 0.07, − 0.02), P = 0.003; β₂ = 0.28(0.05,0.51), P = 0.019 − 0.52(− 0.55, − 0.50), P < 0.001 − 0.52(− 0.55, − 0.50), P < 0.001 − 0.0112 0.22% 0.024
Blood lipids score β₁ = − 0.02(− 0.04, − 0.01), P = 0.032; β₂ = 0.27(0.15,0.40), P < 0.001 − 0.05(− 0.07, − 0.03), P < 0.001 − 0.05(− 0.07, − 0.03), P < 0.001 − 0.0054 1.53% 0.076
Blood glucose score β₁ = − 0.02(− 0.05,0.01), P = 0.298; β₂ = 0.29(0.16,0.41), P < 0.001 − 0.07(− 0.09, − 0.05), P < 0.001 − 0.07(− 0.09, − 0.05), P < 0.001 − 0.0058 1.21% 0.152
Blood pressure score β₁ =− 0.01(− 0.03,0.01), P = 0.418; β₂ = 0.29(0.16,0.41), P < 0.001 -0.05(-0.06, -0.03), P < 0.001 − 0.05(− 0.06, − 0.03), P < 0.001 − 0.0029 1.09% 0.324