TABLE 4.

Evidence of priming with PTx based on anti-PT antibody response (≥2-fold rise on day 7) following aerosol challenge (day 0)^a

Response group	WBC count (103 cells/mm3) on day:			Δ Wt (g) on days:			Lung bac- terial counts (106 CFU/ml) on day:
	0b	7	14	0-7	7-14	0-14	7b	14
Nonrespondersd	5.1	29.9	175.4	0.5	−3.7	−3.3	59.7	469.5
Responderse
All on day 7	5.2	14.3c	23.0c	0.6	0.9c	1.5c	36.1	0.8c
<2-fold rise on day 7	4.8	20.8	30.7	0.8	−0.7	0.0	50.2	3.2
≥2-fold rise on day 7	5.5	11.8c	20.1c	0.6c	2.0c	2.5c	36.5	0.3c
≥10-fold rise on day 14	5.0	14.9c	20.6c	0.5	1.9c	2.4c	NAf	0.3c

^aAll values presented in geometric means.

^bNo statistical difference between any of the groups (P >0.05).

^cStatistically different (P < 0.05) from nonprimed (anti-PT IgG <1 μg/ml) groups.

^dDay 0 anti-PT IgG titer, <1 μg/ml.

^eDay 0 anti-PT IgG titer, ≥1 μg/ml

^fNA, not available.