Table 2.
Mean fractional anisotropy (FA), mean diffusivity (MD), and T1-based fractal dimension (FD) in healthy controls (HC) and multiple sclerosis patients (MS) before (incl.) and after (excl.) lesion masking in grey (GM) and white matter (WM) general structures.
| Metric | GM | WM | ||||
|---|---|---|---|---|---|---|
| HC | MS (incl.) | MS (excl.) | HC | MS (incl.) | MS (excl.) | |
| FA | 0.1301 ± 0.0069 | 0.1329 ± 0.0061 (p < 0.001) |
0.1318 ± 0.0061 (p < 0.05) |
0.286 ± 0.015 | 0.271 ± 0.026 (p < 0.001) |
0.270 ± 0.026 (p < 0.001) |
| MD | 0.787 ± 0.021 | 0.821 ± 0.037 (p < 0.001) |
0.820 ± 0.037 (p < 0.001) |
0.682 ± 0.014 | 0.713 ± 0.031 (p < 0.001) |
0.712 ± 0.030 (p < 0.001) |
| FD | 2.600 ± 0.014 | 2.607 ± 0.015 (p < 0.001) |
2.603 ± 0.014 (p = 0.071) |
2.528 ± 0.015 | 2.502 ± 0.029 (p < 0.001) |
2.499 ± 0.032 (p < 0.001) |
FDR-corrected p-values for statistically significant differences between MS and HC are shown below the metric. For FA in GM Welch, the t-test was used, while the Mann–Whitney U-test was used for the remaining comparisons.