TABLE 2.
Histopathology in the corpus mucosas of H. pylori-infected vaccinated mice in relation to immunization status
| Group | Score for:
|
Protection factorsc | |
|---|---|---|---|
| Atrophya | Inflammationb | ||
| Therapeutic immunization model | |||
| Infected Control | 0 ± 0 | 0.4 ± 0.4 | 1.6 ± 1.9 |
| CT | 1 ± 1.8 | 1 ± 1 | 1.0 ± 0.7 |
| Lysate + CT | 5 ± 2d | 5. ± 1.6d | 10 ± 12 |
| Reinfection model | |||
| Reinfection control | 0 ± 0 | 0.25 ± 0.2 | 1.5 ± 1.5 |
| Infection | 0 ± 0 | 1.3 ± 1 | 4 ± 4.3 |
| CT | 0 ± 0e | 0.8 ± 1e | 18 ± 21 |
| Lysate + CT | 4 ± 1 | 4 ± 0.3 | 40 ± 46 |
Atrophy of the corpus and fundus is defined in the Sydney system of grading gastritis as the loss of acid-secreting parietal cells and zymogen-secreting chief cells in the stomach, graded on a scale of 0 to 6. Individual mice were scored, and the mean score of each group is presented.
Inflammation is defined as infiltration of leukocytes in the lamina propria of gastric tissue, graded on a scale of 0 to 6. Individual mice were scored, and the mean score of each group is presented.
Protection factors were calculated as the ratio of the geometric mean number of bacteria in infected control mice to the number of bacteria in individual vaccinated mice ± SD.
P < 0.001 compared to value for infected control group.
P < 0.001 compared to value for the group immunized with lysate plus CT after reinfection.