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. 2025 Dec 16;17:726. doi: 10.1038/s41467-025-67421-0

Fig. 3. Further comparison between PASTA and other methods using the human lung cancer ST data.

Fig. 3

A Cell annotation of the lung cancer data. We annotated the cells manually referring to the PanglaoDB. B Correlation between the imputation and the truth of pathway genes from PASTA and existing methods over 44 biological pathways. Each Dot represents a correlation value. The center bar represents the median value, and the upper/lower bound of the box shows the 25%/75% quartile with whiskers extending to the minimum and maximum values. Two sided Wilcoxon rank sum test shows significantly better predictions from PASTA compared to the other methods (P < 0.0001, *** shows significant differences). C Pathway enrichment in each cell type. D Comparison of the cell annotation, IRIS cluster, and K-means cluster in three representative areas. E Predicted hallmark pathway expression in tumor and the abjection area from PASTA. Source data are provided as a Source Data file.