Skip to main content
. 2025 Dec 16;17:726. doi: 10.1038/s41467-025-67421-0

Fig. 5. Predicted pathway expression of mouse frontal cortex data.

Fig. 5

A Pathway predictions. PASTA and Tangram showed superior performance. B Overall correlations between the predictions and the ground truth derived from 26 pathways. Each Dot represents a correlation value. The center bar represents the median value, and the upper/lower bound of the box shows the 25%/75% quartile with whiskers extending to the minimum and maximum values. Two sided Wilcoxon rank sum test shows significantly better predictions from PASTA compared to the other methods except for Tangram (P < 0.0001, *** shows significant differences). C Pathway enrichment among each cell type. Seurat generates some false positives under the cluster of endothelial cells. D Pseudotime estimation from PASTA and Tangram predictions projected in UMAP coordinates. The UMAP and the trajectory analysis were conducted using the predicted “pathway-by-cell" matrix. Source data are provided as a Source Data file.