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. 2026 Jan 19;16:2593. doi: 10.1038/s41598-026-36367-8

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Alterations in histone methylation are associated with leukemia development. (a & c) Principal component analysis scatter plot of normalized median of ratios using Diffbind and DESeq2 showing variations between the samples in (a) H3K4me3 differential enrichment and (c) H3K4me1 differential enrichment. (b & d) Volcano plot depicting the differential enrichment of H3K4me3 (b), or H3K4me1 (d) between MNX1-vector transduced FL cells (blue) and empty vector transduced FL cells (Ctrl-grey; left panel) or mice leukemia BM cells (red) and empty vector transduced FL cells (right panel).