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. 2026 Jan 16;16:2398. doi: 10.1038/s41598-025-89666-x

Table 2.

Performance comparison of existing architectures and varying strategies with the proposed approach on the combined dataset. (CA: classwise accuracy (%), BACC: Balanced Accuracy (%)).

Input Class Precision Recall F1 Score Sensitivity Specificity CA BACC
Existing Architectures
E417 H 0.85 0.78 0.81 0.77 0.87 77.81 80.89
G 0.68 0.80 0.74 0.79 0.86 79.88
DR 0.86 0.85 0.86 0.85 0.93 85.10
SNet20 H 0.85 0.68 0.75 0.67 0.89 67.84 80.34
G 0.60 0.90 0.72 0.89 0.77 89.65
DR 0.96 0.84 0.89 0.83 0.98 83.51
EyeNET48 H 0.67 0.45 0.54 0.45 0.75 45.33 53.33
G 0.37 0.54 0.44 0.54 0.61 54.02
DR 0.55 0.61 0.57 0.60 0.71 61.63
Concatenated Images H 0.87 0.70 0.78 0.70 0.89 70.40 78.56
G 0.58 0.84 0.68 0.84 0.77 83.90
DR 0.92 0.81 0.86 0.81 0.96 81.40
Ablation Work
With OD H 0.87 0.75 0.81 0.75 0.89 75.24 82.25
G 0.71 0.81 0.76 0.81 0.87 81.03
DR 0.84 0.91 0.87 0.90 0.91 90.95
With vessels H 0.83 0.81 0.82 0.81 0.85 81.35 82.67
G 0.75 0.79 0.77 0.78 0.90 78.73
DR 0.88 0.88 0.88 0.87 0.94 87.76
Without feature selection H 0.81 0.84 0.83 0.84 0.82 84.24 81.02
G 0.75 0.78 0.77 0.78 0.90 78.1
DR 0.90 0.81 0.85 0.80 0.96 80.85
Proposed Approach
Proposed* (Inline graphic, Inline graphic) H 0.83 0.81 0.82 0.81 0.85 81.00 83.0
G 0.75 0.81 0.78 0.81 0.89 81.00
DR 0.90 0.87 0.89 0.87 0.96 87.00
Proposed* (Inline graphic: 0.87, Inline graphic: 0.782, Inline graphic: 1.0) H 0.91 0.78 0.84 0.78 0.93 78.14 85.23
G 0.69 0.91 0.79 0.91 0.85 91.38
DR 0.92 0.86 0.89 0.86 0.96 86.17