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. 2026 Jan 19;16:2415. doi: 10.1038/s41598-025-23316-0

Table 1.

Incidence and severity of pathological findings.

Group/Findings Vehicle Anti-Fx1A L-NAME L-NAME + Anti-Fx1A
Group size 8 10 10 10
Glomerular injury 0 8 1 10
Grade 1 - 6 1* 9
Grade 2 - 2 - 1
Tubular degeneration/regeneration 0 5 5 9
Grade 1 - 4 3 3
Grade 2 - - 2 4
Grade 3 - 1 - 2
Tubular hyaline casts 0 2 4 7
Grade 1 - 2 4 6
Grade 2 - - - 1
Tubular dilatation 0 1 1 5
Grade 1 - - 1 5
Grade 2 - 1 - -
Interstitial fibrosis (H&E) 0 1 2 2
Grade 1 - - 2 2
Grade 2 - 1 - -
Interstitial fibrosis (PSR) 0 1 3 7
Grade 1 - - 3 6
Grade 2 - - - 1
Grade 3 - 1 - -
Vascular Degeneration 0 0 3 3
Grade 1 - - 3 3

*: only a few glomeruli were affected.