Table 2.
Top pathways enriched by differentially expressed genes in common between all 3 treatment groups.
| -log(p-value) | Ratio | z-score | Upstream Regulator | z-score | |
|---|---|---|---|---|---|
| Ingenuity Canonical Pathways | |||||
| Mitochondrial dysfunction | 6.14 | 0.10 | -2.48 | TP53 | 2.09 |
| Oxidative phosphorylation | 4.76 | 0.13 | 3.87 | KRAS | 0.08 |
| Nitric oxide signaling in the cardiovascular system | 4.40 | 0.13 | 2.31 | beta-estradiol | 3.84 |
| Detoxification of reactive oxygen species | 4.28 | 0.22 | 2.83 | ESRRA | 5.10 |
| Apelin muscle signaling | 4.23 | 0.19 | 2.00 | STAT6 | 0.91 |
| Relaxin signaling | 4.17 | 0.11 | 3.00 | IL4 | 4.81 |
| Estrogen receptor signaling | 4.17 | 0.08 | 4.15 | HNF4A | 1.71 |
| Apelin endothelial signaling | 4.14 | 0.11 | 3.00 | MYC | 4.90 |
| Cardiac β-adrenergic signaling | 3.86 | 0.10 | 0.38 | TGFB1 | 2.97 |
| Huntington’s disease signaling | 3.77 | 0.08 | 1.51 | TEAD1 | 4.34 |
| Oxytocin in spinal neurons signaling | 3.59 | 0.20 | 2.65 | APP | 1.68 |
| Ephrin-B signaling | 3.50 | 0.14 | 2.12 | HTT | 0.86 |
| Signaling by Rho family GTPases | 3.36 | 0.08 | 3.87 | SPP1 | 4.14 |
| Thrombin signaling | 3.11 | 0.08 | 3.16 | methylprednisolone | 1.75 |
| Mitochondrial translation | 3.06 | 0.12 | 3.32 | CPT1B | -1.51 |
| Thrombin signalling through proteinase activated receptors (PARs) | 2.99 | 0.19 | 2.45 | lipopolysaccharide | 3.21 |
| mTOR Signaling | 2.95 | 0.08 | 1.27 | EGF | 3.94 |
| Platelet homeostasis | 2.88 | 0.12 | 3.16 | pirinixic acid | 3.42 |
| Nonsense-mediated decay (NMD) | 2.86 | 0.10 | 3.46 | ||
| Protein ubiquitination | 2.85 | 0.08 | 4.58 | ||
| Ingenuity Toxicity Lists | |||||
| Mitochondrial dysfunction | 7.24 | 0.10 | |||
| Renal necrosis/cell death | 5.65 | 0.07 | |||
| Genes downregulated in response to chronic renal failure | 3.48 | 0.40 | |||
| RAR activation | 2.41 | 0.06 | |||
| Cell cycle: G1/S checkpoint regulation | 1.85 | 0.10 | |||
| Renal Proximal Tubule Toxicity Biomarker Panel | 1.77 | 0.15 | |||
| Oxidative stress | 1.73 | 0.11 | |||
| Fatty acid metabolism | 1.52 | 0.08 | |||
| NRF2-mediated oxidative stress response | 1.47 | 0.06 | |||
| Increases renal damage | 1.44 | 0.07 | |||
| TR/RXR activation | 1.31 | 0.07 | |||
| Increases renal proliferation | 1.30 | 0.06 | |||
-log(p-value) of enrichment represents strength of association, ratio = number of genes affected in the dataset versus total number of genes in the pathway, z-score ascribes directionality (positive = predicted activation, negative = predicted inhibition).