Table 3.
Top pathways in common between rat combo treatment and published human transcriptomic profiles.
| L-NAME + Anti-Fx1A | Park 2022 | Nakagawa 2015 | Song 2009 | |||||
|---|---|---|---|---|---|---|---|---|
| -log(p-value) | z-score | -log(p-value) | z-score | -log(p-value) | z-score | -log(p-value) | z-score | |
| Canonical Pathways | ||||||||
| Pathogen Induced Cytokine Storm Signaling Pathway | 6.10 | 6.06 | 5.06 | 5.73 | 4.90 | 6.94 | 2.59 | 5.19 |
| Phagosome Formation | 4.83 | 4.31 | 4.00 | 5.58 | 7.38 | 8.32 | 5.02 | 3.15 |
| Molecular Mechanisms of Cancer | 8.48 | 3.95 | 3.81 | 4.20 | 12.70 | 7.47 | 7.61 | 5.08 |
| Multiple Sclerosis Signaling Pathway | 4.58 | 3.92 | 5.11 | 6.62 | 5.85 | 6.41 | 1.16 | 3.45 |
| Extracellular Matrix Organization | 2.92 | 4.60 | 7.10 | 5.90 | 4.01 | 3.32 | 17.76 | 5.88 |
| Pulmonary Fibrosis Idiopathic Signaling Pathway | 6.18 | 2.77 | 3.88 | 4.51 | 7.89 | 4.83 | 17.11 | 6.55 |
| S100 Family Signaling Pathway | 3.07 | 3.10 | 1.35 | 3.64 | 9.07 | 8.69 | 3.10 | 3.15 |
| RHO GTPase Cycle | 9.44 | 1.98 | 11.61 | 5.74 | 7.98 | 5.16 | 12.44 | 5.68 |
| Integrin Cell Surface Interactions | 3.27 | 4.69 | 6.51 | 4.87 | 2.66 | 3.66 | 13.12 | 4.73 |
| Neuroinflammation Signaling Pathway | 2.04 | 3.89 | 5.04 | 4.84 | 6.16 | 5.47 | 4.21 | 3.41 |
| Upstream Regulators | ||||||||
| Lipopolysaccharide | 49.33 | 8.50 | 52.86 | 6.98 | 24.85 | 9.90 | 67.49 | 10.81 |
| Interferon alpha | 10.66 | 8.07 | 30.01 | 8.00 | 4.91 | 6.68 | 18.55 | 7.51 |
| TNF | 35.26 | 7.45 | 32.60 | 4.88 | 27.92 | 9.06 | 72.23 | 8.16 |
| Poly rI: rC-RNA | 17.81 | 7.06 | 38.09 | 5.53 | 4.79 | 8.11 | 20.65 | 7.27 |
| IFNG | 36.42 | 8.53 | 41.79 | 5.98 | 16.03 | 5.66 | 42.21 | 7.33 |
| AGT | 22.62 | 5.74 | 22.16 | 5.15 | 15.67 | 6.06 | 57.82 | 8.56 |
| CSF2 | 11.17 | 5.82 | 23.00 | 4.61 | 14.69 | 8.54 | 11.82 | 3.85 |
| Tetradecanoylphorbol Acetate | 12.11 | 5.19 | 12.41 | 1.95 | 23.97 | 6.49 | 22.17 | 8.06 |
| OSM | 5.05 | 4.75 | 12.17 | 4.63 | 18.81 | 6.26 | 40.52 | 5.82 |
| Alpha Catenin | 10.01 | -5.93 | 9.98 | -4.67 | 2.53 | -3.75 | 21.01 | -7.00 |
-log(p-value) of enrichment represents strength of association, z-score ascribes directionality (positive = predicted activation, negative = predicted inhibition).