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. 2026 Jan 19;16:2561. doi: 10.1038/s41598-025-32494-w

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of the prescription dose of the HDR brachytherapy boost treatment (single fraction) to EBRT on target , TCP, , and UTCP. Values are obtained by plan selection under scenario (i) for each prescription dose over the whole cohort of patients. The red dashed lines illustrate the median UTCP according to the current prescription used at CHUQ-UL (15 Gy). The green dashed-dotted lines illustrate the prescription (10 Gy) that maximizes the median UTCP for the whole cohort of patients.

Inline graphic — Effect of the prescription dose of the HDR brachytherapy boost treatment (single fraction) to EBRT on target , TCP, , and UTCP. Values are obtained by plan selection under scenario (i) for each prescription dose over the whole cohort of patients. The red dashed lines illustrate the median UTCP according to the current prescription used at CHUQ-UL (15 Gy). The green dashed-dotted lines illustrate the prescription (10 Gy) that maximizes the median UTCP for the whole cohort of patients.