Table 2.
Descriptive statistics of the analytical sample by late-onset epilepsy and Alzheimer’s disease (AD) status, UCLA ATLAS patient population (N = 16,500)a.
| Late-onset epilepsy | Alzheimer’s disease | |||||
|---|---|---|---|---|---|---|
| Cases | Controls | P-value | Cases | Controls | P-value | |
| N = 658 | N = 15,842 | N = 376 | N = 16,124 | |||
| Primary outcome(s) | ||||||
| Alzheimer’s disease (yes) | 44 (6.7%) | 332 (2.1%) | < 0.001* | 376 (100%) | 0 (0%) | - |
| Late onset epilepsy (yes) | 658 (100%) | 0 (0%) | - | 44 (12%) | 614 (3.8%) | < 0.001* |
| Demographics | ||||||
| Age at first visit (in years) | 58.19 (10.36) | 56.15 (11.60) | < 0.001* | 62.08 (11.83) | 56.09 (11.52) | < 0.001* |
| Age at last visit (in years) | 75.95 (6.77) | 73.26 (7.59) | < 0.001* | 82.01 (5.93) | 73.16 (7.49) | < 0.001* |
| Sex (female) | 298 (45%) | 7,794 (49%) | 0.049* | 207 (55%) | 7,885 (49%) | 0.02* |
| EHR record length (in years) | 17.76 (9.81) | 17.11 (10.24) | 0.03* | 19.93 (10.92) | 17.07 (10.20) | < 0.001* |
| Deceased (yes) | 141 (21%) | 1,221 (7.7%) | < 0.001* | 67 (18%) | 1,295 (8.0%) | < 0.001* |
| Health conditions | ||||||
| Hypertension (yes) | 526 (80%) | 10,849 (68%) | < 0.001* | 296 (79%) | 11,079 (69%) | < 0.001* |
| Diabetes (yes) | 188 (29%) | 3,516 (22%) | < 0.001* | 103 (27%) | 3,601 (22%) | 0.02* |
| Stroke (yes) | 48 (7.3%) | 315 (2.0%) | < 0.001* | 54 (14%) | 309 (1.9%) | < 0.001* |
| Hyperlipidemia (yes) | 524 (80%) | 11,589 (73%) | < 0.001* | 304 (81%) | 11,809 (73%) | < 0.001* |
| AD genetics | ||||||
| APOE-ε4 count | 0.5 | < 0.001* | ||||
| 0 | 483 (73%) | 11,932 (75%) | 211 (56%) | 12,204 (76%) | ||
| 1 | 167 (25%) | 3,707 (23%) | 142 (38%) | 3,732 (23%) | ||
| 2 | 8 (1.2%) | 203 (1.3%) | 23 (6.1%) | 188 (1.2%) | ||
| AD PRS with APOE region | 0.11 (1.23) | 0.06 (1.18) | 0.2 | 0.28 (1.21) | 0.05 (1.18) | < 0.001* |
APOE apolipoprotein E, EHR electronic health record.
[a] Summary statistics are displayed as n (%) for categorical variables, and mean (SD) for continuous variables. P-values were calculated with Pearson’s Chi-squared test or Wilcoxon rank sum test as appropriate.
*Statistical significance at P-value < 0.05 level.