Table 5.

Associations between shared Alzheimer’s disease (AD)-late-onset epilepsy (LOE) shared genetic risk score (GRS), APOE-ε4 count, and AD/LOE status, UCLA ATLAS patient population, with multi-task elastic net modeling testing sample (N = 2,002)^a.

Phenotype	Variation explained	OR (95% CI)	P-value
APOE-ε4 count
AD or LOE	1.44%	1.90 (1.41, 2.53)	< 0.001*
AD only	7.57%	4.31 (2.75, 6.78)	< 0.001*
LOE only	0.01%	1.05 (0.70, 1.54)	0.81
AD-LOE shared GRS (full)
AD or LOE	1.79%	1.42 (1.22, 1.64)	< 0.001*
AD only	6.87%	2.10 (1.64, 2.71)	< 0.001*
LOE only	0.29%	1.16 (0.97, 1.38)	0.1
AD-LOE shared GRS (without APOE)
AD or LOE	0.63%	1.24 (1.06, 1.45)	0.01*
AD only	0.72%	1.28 (0.99, 1.66)	0.056
LOE only	0.49%	1.21 (1.01, 1.46)	0.04*

APOE apolipoprotein E, CI confidence interval, OR odds ratio.

[a] Model adjustments include age at last visit, sex, and first five ancestry-specific principal components.