Table 6.

Associations between Alzheimer’s disease (AD) and late-onset epilepsy (LOE), all of Us patient population (N = 52,493)^a.

	AD ~ LOE			LOE ~ AD
	N	HR [95% CI]	P-value	N	HR [95% CI]	P-value
Basic modela
Cox proportional hazard	52,319	3.95 (2.77, 5.63)	< 0.001*	52,206	2.96 (1.89, 4.61)	< 0.001*
Fine and Gray	52,319	2.47 (1.69, 3.60)	< 0.001*	52,206	1.98 (1.22, 3.20)	0.005*
Adjusted for AD geneticsb
Cox proportional hazard	52,319	3.96 (2.78, 5.64)	< 0.001*	52,206	2.96 (1.89, 4.62)	< 0.001*
Fine and Gray	52,319	2.49 (1.71, 3.63)	< 0.001*	52,206	1.98 (1.22, 3.21)	0.001*

CI confidence interval, EHR electronic health record.

[a]Basic model adjustments include age at first visit, sex, EHR record length, hypertension, diabetes, stroke, and hyperlipidemia status.

[b] Additionally adjusted for APOE-ε4 count and AD polygenic risk score (without APOE region) in [b].