Table 7.

Associations between shared Alzheimer’s disease (AD)-late-onset epilepsy (LOE) shared genetic risk score (GRS), APOE-ε4 count, and AD/LOE status, all of Us patient population, genetic sample (N = 23,037)^a.

Phenotype	Variation explained	OR (95% CI)	P-value
APOE-ε4 count
AD or LOE	0.04%	1.16 (1.01, 1.32)	0.03*
AD only	0.46%	1.98 (1.42, 2.84)	< 0.001*
LOE only	< 0.01%	1.04 (0.90, 1.20)	0.59
AD-LOE shared GRS (full)
AD or LOE	0.10%	1.09 (1.04, 1.14)	< 0.001*
AD only	2.02%	1.54 (1.40, 1.69)	< 0.001*
LOE only	< 0.01%	1.01 (0.96, 1.06)	0.80
AD-LOE shared GRS (without APOE)
AD or LOE	0.01%	1.04 (0.95, 1.14)	0.41
AD only	0.06%	1.17 (0.96, 1.42)	0.12
LOE only	0.02%	1.09 (0.98, 1.20)	0.11

APOE apolipoprotein E, CI confidence interval, OR odds ratio.

[a] Model adjustments include age at last visit, sex, and first five ancestry-specific principal components.