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. 2025 Dec 15;12(1):9. doi: 10.1038/s41537-025-00712-z

Fig. 3. Semantic network of all items to TLC backbone.

Fig. 3

The network obtained by linking each item from the seven FTD scales to its single most similar TLC item, revealing four distinct clusters of semantically related symptoms. In the bottom-left cluster (Group 1), items reflect muddled communication with incomprehensible elements, meaning distortion, and word substitution that heighten confusion. The middle-top cluster (Group 2) highlights abrupt topic shifts, repeated words or subjects, speech interruptions, and lapses in recalling previous statements. The top-right cluster (Group 3) centers on unfounded conclusions, irrelevant replies, lack of thought continuity, and disjointed ideas, resulting in inconsistent narrative structure. Finally, the bottom-right cluster (Group 4) illustrates off-topic wandering, weak context association, and minimal connecting “cementing words,” exacerbating difficulties in word sequencing. Items are color-coded by the rating scale prefix (e.g., TALD, TLC, CLANG, BIT, SAPS-SANS, PANSS, TLI), illustrating how conceptually similar symptoms from different scales co-locate in the same region of the network. For a full description of these four groups and the corresponding items, see Table 1. For a version of this division where edges represent similarity, see supplemental Fig. 1.