Fig. 3. Oncoplot showing an overview of the molecular landscape of somatic aberrations (n = 219).

The oncoplot is divided into three categories based on the stage in which the tested tissue was originally obtained. Rows show the affected genes sorted per pathway; columns represent affected individuals. The frequency of gene alterations is shown on the right side. The upper histogram shows non-synonymous mutations per mb (nsTMB), the colour of the bar represents the microsatellite status. The type of aberration is shown in the legend below. Mono-allelic losses, without a second hit, were omitted from the oncoplot except for BRCA1/2. Cases with more than one aberration in a gene are represented by multi-hit. In case of loss of the wild-type allele this is indicated with a dot. The bottom row shows information about the tissue samples and tumour stage wherein the aberration was found.