FIG. 1.
(A) Inhibition of beauvericin-induced internucleosomal DNA fragmentation by O. tsutsugamushi infection. Chromosomal DNA from THP-1 cells was separated at various time points following treatment with beauvericin. (B) Immunoblotting of THP-1 cells with anti-PARP antibody at various time points after treatment with beauvericin. Lysates of THP-1 cells were separated by electrophoresis and stained with anti-PARP antibody. Cells were preconditioned by mock treatment or treatment with live O. tsutsugamushi (LOT) and heat-killed O. tsutsugamushi (HOT) 18 h before treatment with beauvericin.