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. 2025 Mar 31;10(1):Doc009. doi: 10.34865/mb9997e10_1or

Tab.1. Reported patch test results for N,N-dimethyl-p-toluidine in patients with suspected contact allergy.

Persons tested Test substance, concentration (vehicle) Results Contact / comments References
case reports
60-year-old joiner with early loosening of a hip prosthesis no data positive (palpable erythema after 48 and 96 hours) no skin reactions after occupational exposure to numerous glues Haddad et al. 1995
1 dental worker 2% (petrolatum) positive (no other details) patient with dermatitis 4 weeks after the beginning of exposure to dental materials Rai et al. 2014
1 dental student with vesiculobullous changes on his fingertips no data positive (no other details) additional positive reaction to a monomer liquid handled by the student (no other details) Santosh et al. 1999
62-year-old housewife with diffuse redness and discomfort on the oral mucous membrane after receiving new dentures 1% (petrolatum) 1+ and 2+ (after 48 and 72 hours, respectively) healing of the changes after the dentures had not been worn for a prolonged period Tosti et al. 1990
79-year-old woman with discomfort (pain and burning) on the tongue several months after receiving new dentures 5% (petrolatum) 2+ (after 48 and 72 hours) additional 2+ reaction to abrasion material of the prosthesis; no reaction to 5% N,N-dimethyl-p-toluidine in 139 other patients tested (no other details); symptoms reversible after a period without using the dentures Verschueren and Bruynzeel 1991
results of patch tests in larger cohorts
22 patients with burning mouth syndrome 5% (petrolatum) positive in 3 of 22 (no other details) test period not reported; 20 of the 22 patients with complete or partial dentures Dutrée-Meulenberg et al. 1992
38 patients with implant intolerance no data positive in 0 of 38 test period not reported Eben et al. 2010
725 patients 2% (petrolatum) positive in 1 of 725 (no other details) test period: 8/1992 to 7/1994; in addition, 10 × questionable and 1 × irritant reactions; overlapping of the cohort with that of Richter and Geier (1996) Gebhardt and Geier 1996
40 dental technicians 2% (petrolatum) positive in 0 of 40 test period: 1/1990 to 7/1993 Gebhardt et al. 1996
66 patients with planned total hip replacements, 14 patients with a stable hip prosthesis and 50 patients with loosening of their hip prosthesis 2% (petrolatum) positive in 1 of 66, 0 of 14 and 2 of 50 (no other details) test period: 1/2001 to 5/2004 Granchi et al. 2006
15 patients with early loosening of their hip prosthesis, 55 patients with total hip replacements 0.5% (no data) positive in 7 of 15 and in 0 of 55 (no other details) test period not reported Haddad et al. 1996
53 dental workers with self-reported history of dermatitis on the hands 2% (petrolatum) positive in 1 of 53 (1+, after 96 hours) positive in a 42-year-old female orthodontist; relevance of the reaction not reported Hill et al. 1998
43 patients 2% (petrolatum) positive in 1 of 43 (no other details) test period: 1981 to 1988; reaction was not considered to be relevant; testing with plastic and glue constituents Holness and Nethercott 1997
9238 patients 2% (petrolatum) positive in 9 of 9238 (1+, after 72 hours) test period: 1997 to 2016; in addition 46 × questionable and 11 × irritant reactions; the 9 patients reacted on average to 6 different allergens IVDK 2017
53 patients with burning mouth syndrome and dental prostheses 30% (olive oil) positive in 1 of 53 (2+, after 48 or 72 hours) positive in 1 patient with complete upper dentures; no reaction to test formulation in 20 control persons Kaaber et al. 1979
143 patients 5% (petrolatum) positive in 0 of 143 testing over a period of 3 years with plastic and glue constituents; possible overlapping of the cohort with that of Kanerva et al. (1999) Kanerva et al. 1997
309 patients 5% (petrolatum) positive in 0 of 309 test period: 1991 to 1996; testing with plastic and glue constituents; in addition, 1 × irritant reaction; possible overlapping of the cohort with that of Kanerva et al. (1997) Kanerva et al. 1999
79 dentists and 46 dental assistants 5% (petrolatum) positive in 0 of 125 test period: 1990 to 2000 Kiec-Swierczyńska and Krecisz 2002
150 dental technician students 5% (petrolatum) positive in 9 of 150 (no other details) positive reaction in 37 and 22 technicians to 2% formaldehyde and 5% N,N-bis(2-hydroxyethyl)-p-toluidine (in petrolatum), respectively Lyapina et al. 2019
756 patients 2% (petrolatum) positive in 1 of 756 (no other details) test period: 1/1990 to 7/1993; overlapping of the cohort with that of Gebhardt and Geier (1996) Richter and Geier 1996
35 dental technicians with occupational dermatitis on the hands 2% (petrolatum) positive in 1 of 35 (no other details) test period: 2/1993 to 6/1994; positive reaction in 1 of a total of 55 tested technicians; relevance unclear Rustemeyer and Frosch 1996
33 patients with lichenoid lesions of the oral mucosa 2% (petrolatum) positive in 1 of 33 (no other details) test period: 2009 to 2012 Şahin et al. 2016
30 patients with lesions of the oral mucosa or lips no data positive in 0 of 30 test period: 1/1990 to 7/1998 Santosh et al. 1999
444 patients 5% (petrolatum) 0 of 444 test period: 2002 to 2007; irritant reaction in 1.6% of the patients; testing with plastic and glue constituents Shmidt et al. 2010
115 patients with lichenoid lesions of the oral mucosa 2% (petrolatum) positive in 2 of 115 (no other details) test period: 11/2007 to 6/2014 Suter and Warnakulasuriya 2016
113 patients with implant intolerance 2% (petrolatum) positive in 0 of 113 test period not reported Thomas et al. 2008
250 patients with suspected allergy to bone implants 2% (petrolatum) positive in 0 of 250 test period: 8/2010 to 9/2013 Thomas et al. 2015