TABLE 1.
OS incorporation and coupling method used for CRM197 conjugates
| Conjugate | OS | Coupling method | OS incorporation |
|---|---|---|---|
| 1 | 1b | Adipic acid | 4.0 |
| 2 | 1b | Squarate | 4.8 |
| 3 | 1b | Squarate | 11.5 |
| 4 | 1b | Squarate | 23.8 |
| 5 | 3b | Squarate | 11.5 |
| 6 | 3b | Adipic acid | 8.5 |
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