TABLE 2.

IgG antibody response to Pn14PS and to CRM197 in mice immunized with OS-CRM197 conjugates prepared with different linkers^a

Immunogen	Linker	Anti-Pn14PS IgG (geometric mean titer) after the following no. of vaccinations:
		One	Two
Conjugate 1	Adipic acid	1,176	442,218
Conjugate 2	Squarate	498	111,813
Conjugate 5	Squarate	429	787
Conjugate 6	Adipic acid	366	9,323
Saline		NDb	347

^aMice (five mice per group) were immunized subcutaneously with 2.5 μg of OS conjugated to CRM197.

^bND, not determined.